Polymer-peptide conjugate hydrogels:towards controlled drug delivery

Sohdi, Arun, Campbell, Darren and Topham, Paul (2012). Polymer-peptide conjugate hydrogels:towards controlled drug delivery. Chiang Mai Journal of Science, 39 (3), pp. 351-372.

Abstract

Peptide-based materials exhibit remarkable supramolecular self-assembling behavior, owing to their overwhelming propensity to from hierarchical structures from a-helices and ß-sheets. Coupling a peptide sequence to a synthetic polymer chain allows greater control over the final physical properties of the supermolecular material. So-called ‘polymer-peptide conjugates’ can be used to create biocompatible hydrogels which are held together by reversible physical interactions. Potentially, the hydrogels can be loaded with aqueous-based drug molecules, which can be injected into targeted sites in the body if they can exhibit a gel-sol-gel transition under application and removal of a shear force. In this review, we introduce this topic to readers new to the field of polymer-peptide conjugates, discussing common synthetic strategies and their self-assembling behavior. The lack of examples of actual drug delivery applications from polymer-peptide conjugates is highlighted in an attempt to incite progress in this area.

Divisions: Engineering & Applied Sciences > Chemical engineering & applied chemistry
Engineering & Applied Sciences > Polymer and advanced materials research group
Uncontrolled Keywords: polymer-peptide conjugates,hydrogels,drug delivery,Physics and Astronomy(all),Mathematics(all),Biochemistry, Genetics and Molecular Biology(all),Chemistry(all),Materials Science(all)
Full Text Link: http://it.science.cmu.ac.th/ejournal/journalDetail.php?journal_id=1197
Related URLs: http://www.scopus.com/inward/record.url?scp=84865188443&partnerID=8YFLogxK (Scopus URL)
Published Date: 2012-07
Authors: Sohdi, Arun
Campbell, Darren
Topham, Paul ( 0000-0003-4152-6976)

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