Oxidative and inflammatory status in Type 2 diabetes patients with periodontitis

Allen, Edith M., Matthews, John B., O'Halloran, Domhnall J., Griffiths, Helen R and Chapple, Iain L. Oxidative and inflammatory status in Type 2 diabetes patients with periodontitis. Journal of Clinical Periodontology, 38 (10), pp. 894-901.


Aim: To determine the impact of periodontitis on oxidative/inflammatory status and diabetes control in Type 2 diabetes. Materials and Methods: A comparative study of 20 Type 2 diabetes patients with periodontitis [body mass index (BMI) 31+5], 20-age/gender-matched, non-periodontitis Type 2 diabetes controls (BMI 29+6) and 20 non-diabetes periodontitis controls (BMI 25+4) had periodontal examinations and fasting blood samples collected. Oxidative stress was determined by plasma small molecule antioxidant capacity (pSMAC) and protein carbonyl levels; inflammatory status by total/differential leucocytes, fibrinogen and high sensitivity C-reactive protein (hsCRP); diabetes status by fasting glucose, HbA1c, lipid profile, insulin resistance and secretion. Statistical analysis was performed using SPSS. Results: pSMAC was lower (p=0.03) and protein carbonyls higher (p=0.007) in Type 2 diabetes patients with periodontitis compared with those without periodontitis. Periodontitis was associated with significantly higher HbA1c (p=0.002) and fasting glucose levels (p=0.04) and with lower ß-cell function (HOMA-ß; p=0.01) in diabetes patients. Periodontitis had little effect on inflammatory markers or lipid profiles, but Type 2 diabetes patients with periodontitis had higher levels of hsCRP than those without diabetes (p=0.004) and the lowest levels of HDL-cholesterol of all groups. Conclusion: Periodontitis is associated with increased oxidative stress and compromised glycaemic control in Type 2 diabetes patients.

Publication DOI: https://doi.org/10.1111/j.1600-051X.2011.01764.x
Divisions: Life & Health Sciences
Life & Health Sciences > Applied Health Research Group
Life & Health Sciences > Biomedical Sciences research group
Additional Information: © 2011 John Wiley & Sons A/S.
Uncontrolled Keywords: adult,aged,B-lymphocytes,blood glucose,body mass index,c-reactive protein,case-control studies,HDL cholesterol,chronic periodontitis,type 2 diabetes mellitus,female,glycosylated hemoglobin A,humans,insulin resistance,male,middle aged,oxidative stress,protein carbonylation,diabetes,inflammation,periodontitis,Periodontics
Full Text Link: http://www.scopus.com/inward/record.url?scp=80052764761&partnerID=8YFLogxK
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Authors: Allen, Edith M.
Matthews, John B.
O'Halloran, Domhnall J.
Griffiths, Helen R
Chapple, Iain L.


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