Circadian gene variants and susceptibility to type 2 diabetes:a pilot study

Kelly, M. Ann, Rees, Simon D., Hydrie, M. Zafar I., Shera, A. Samad, Bellary, Srikanth, O'Hare, J. Paul, Kumar, Sudhesh, Taheri, Shahrad, Basit, Abdul, Barnett, Anthony H., DIAGRAM Consortium and SAT2D consortium (2012). Circadian gene variants and susceptibility to type 2 diabetes:a pilot study. PLoS ONE, 7 (4),

Abstract

Disruption of endogenous circadian rhythms has been shown to increase the risk of developing type 2 diabetes, suggesting that circadian genes might play a role in determining disease susceptibility. We present the results of a pilot study investigating the association between type 2 diabetes and selected single nucleotide polymorphisms (SNPs) in/near nine circadian genes. The variants were chosen based on their previously reported association with prostate cancer, a disease that has been suggested to have a genetic link with type 2 diabetes through a number of shared inherited risk determinants.

Publication DOI: https://doi.org/10.1371/journal.pone.0032670
Divisions: Life & Health Sciences > Biosciences
Life & Health Sciences
Additional Information: © 2012 Kelly et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Uncontrolled Keywords: Agricultural and Biological Sciences(all),Biochemistry, Genetics and Molecular Biology(all),Medicine(all)
Full Text Link: http://www.plos ... al.pone.0032670
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
Published Date: 2012-04-02
Authors: Kelly, M. Ann
Rees, Simon D.
Hydrie, M. Zafar I.
Shera, A. Samad
Bellary, Srikanth
O'Hare, J. Paul
Kumar, Sudhesh
Taheri, Shahrad
Basit, Abdul
Barnett, Anthony H.
, DIAGRAM Consortium
, SAT2D consortium

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License: Creative Commons Attribution


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