Research update:alpha7 nicotinic acetylcholine receptor mechanisms in Alzheimer's disease

Parri, H. Rheinallt, Hernandez, Caterina M. and Dineley, Kelly T. (2011). Research update:alpha7 nicotinic acetylcholine receptor mechanisms in Alzheimer's disease. Biochemical Pharmacology, 82 (8), pp. 931-942.

Abstract

Aberrant amyloid-ß peptide (Aß) accumulation along with altered expression and function of nicotinic acetylcholine receptors (nAChRs) stand prominently in the etiology of Alzheimer's disease (AD). Since the discovery that Aß is bound to a7 nAChRs under many experimental settings, including post-mortem AD brain, much effort has been expended to understand the implications of this interaction in the disease milieu. This research update will review the current literature on the a7 nAChR-Aß interaction in vitro and in vivo, the functional consequences of this interaction from sub-cellular to cognitive levels, and discuss the implications these relationships might have for AD therapies.

Publication DOI: https://doi.org/10.1016/j.bcp.2011.06.039
Divisions: Life & Health Sciences
Life & Health Sciences > Pharmacy
Additional Information: Copyright © 2011 Elsevier Inc. All rights reserved.
Uncontrolled Keywords: allosteric regulation,Alzheimer disease,amyloid beta-peptides,animals binding sites,cognition,humans,learning,memory,protein binding,nicotinic receptors,signal transduction,synaptic transmission,Biochemistry,Pharmacology
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
Published Date: 2011-10-15
Authors: Parri, H. Rheinallt ( 0000-0002-1412-2688)
Hernandez, Caterina M.
Dineley, Kelly T.

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