The role of zinc in the anti-tumour and anti-cachectic activity of D-myo-inositol 1,2,6-triphosphate

Russell, Steven, Siren, Pontus M.A., Siren, Matus J. and Tisdale, Michael (2010). The role of zinc in the anti-tumour and anti-cachectic activity of D-myo-inositol 1,2,6-triphosphate. British Journal of Cancer, 102 (5), 833–836.

Abstract

Background: D-myo-inositol-1,2,6-triphosphate (a-trinositol, AT) is a polyanionic molecule capable of chelating divalent metal ions with anti-tumour and anti-cachectic activity in a murine model. Methods: To investigate the role of zinc in this process, mice bearing cachexia-inducing MAC16 tumour were treated with AT, with or without concomitant administration of ZnSO4. Results: At a dose of 40mgkg-1, AT effectively attenuated both weight loss and growth of the MAC16 tumour, and both effects were attenuated by co-administration of Zn2+. The concentration of zinc in gastrocnemius muscle increased with increasing weight loss, whereas administration of AT decreased the levels of zinc in plasma, skeletal muscle and tumour, which were restored back to control values after administration of ZnSO4. Conclusion: These results suggest that zinc is important in both tumour growth and cachexia in this animal model.

Publication DOI: https://doi.org/10.1038/sj.bjc.6605562
Divisions: Life & Health Sciences > Pharmacy
Life & Health Sciences
Additional Information: From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ To obtain permission to re-use content from this article visit RightsLink.
Uncontrolled Keywords: cachexia,a-trinositol,zinc,tumour growth,Cancer Research,Oncology
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
http://www.natu ... l/6605562a.html (Publisher URL)
Published Date: 2010-02-09
Authors: Russell, Steven
Siren, Pontus M.A.
Siren, Matus J.
Tisdale, Michael

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