Apoptosis of neurons and oligodendrocytes in the spinal cord of spinal hyperostotic mouse (twy/twy):possible pathomechanism of human cervical compressive myelopathy

Uchida, Kenzo, Nakajima, Hideaki, Watanabe, Shuji, Yayama, Takafumi, Guerrero, Alexander R., Inukai, Tomoo, Hirai, Takayuki, Sugita, Daisuke, Johnson, William E and Baba, Hisatoshi (2012). Apoptosis of neurons and oligodendrocytes in the spinal cord of spinal hyperostotic mouse (twy/twy):possible pathomechanism of human cervical compressive myelopathy. European Spine Journal, 21 (3), pp. 490-497.

Abstract

Cervical compressive myelopathy is the most serious complication of cervical spondylosis or ossification of the posterior longitudinal ligament (OPLL) and the most frequent cause of spinal cord dysfunction. There is little information on the exact pathophysiological mechanism responsible for the progressive loss of neural tissue in the spinal cord of such patients. In this study, we used the spinal hyperostotic mouse (twy/twy) as a suitable model of human spondylosis, and OPLL to investigate the cellular and molecular changes in the spinal cord. Mutant twy/twy mouse developed ossification of the ligamentum flavum at C2-C3 and exhibited progressive paralysis.

Publication DOI: https://doi.org/10.1007/s00586-011-2025-x
Divisions: Life & Health Sciences > Biosciences
Life & Health Sciences
Additional Information: Creative Commons Attribution. © The Author(s) 2011. The original publication is available at www.springerlink.com
Uncontrolled Keywords: Surgery,Orthopedics and Sports Medicine
Full Text Link: http://www.spri ... 22ggq103411194/
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
Published Date: 2012-03
Authors: Uchida, Kenzo
Nakajima, Hideaki
Watanabe, Shuji
Yayama, Takafumi
Guerrero, Alexander R.
Inukai, Tomoo
Hirai, Takayuki
Sugita, Daisuke
Johnson, William E
Baba, Hisatoshi

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License: Creative Commons Attribution


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