Trigger release liposome systems:local and remote controlled delivery?

Bibi, Sagida; Lattmann, Eric; Mohammed, Afzal-Ur-Rahman and Perrie, Yvonne (2012). Trigger release liposome systems:local and remote controlled delivery? Journal of Microencapsulation, 29 (3), pp. 262-276.

Abstract

Target-specific delivery has become an integral area of research in order to increase bioavailability and reduce the toxic effects of drugs. As a drug-delivery option, trigger-release liposomes offer sophisticated targeting and greater control-release capabilities. These are broadly divided into two categories; those that utilise the local environment of the target site where there may be an upregulation in certain enzymes or a change in pH and those liposomes that are triggered by an external physical stimulus such as heat, ultrasound or light. These release mechanisms offer a greater degree of control over when and where the drug is released; furthermore, targeting of diseased tissue is enhanced by incorporation of target-specific components such as antibodies. This review aims to show the development of such trigger release liposome systems and the current research in this field.

Publication DOI: 10.3109/02652048.2011.646330
Divisions: Life & Health Sciences > Pharmacy
Life & Health Sciences
Life & Health Sciences > Health Sciences
Life & Health Sciences > Applied Health Research Group
Related URLs:
Uncontrolled Keywords: vesicles,liposomes,trigger release ,photosensitive,ultrasound,enzyme-triggered release,thermosensitive,Pharmaceutical Science,Colloid and Surface Chemistry,Physical and Theoretical Chemistry,Bioengineering,Organic Chemistry
Published Date: 2012-05

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