Functional proteomics to dissect tyrosine kinase signalling pathways in cancer

Kolch, Walter and Pitt, Andrew (2010). Functional proteomics to dissect tyrosine kinase signalling pathways in cancer. Nature Reviews: Cancer, 10 (9), pp. 618-629.

Abstract

Advances in the generation and interpretation of proteomics data have spurred a transition from focusing on protein identification to functional analysis. Here we review recent proteomics results that have elucidated new aspects of the roles and regulation of signal transduction pathways in cancer using the epidermal growth factor receptor (EGFR), ERK and breakpoint cluster region (BCR)-ABL1 networks as examples. The emerging theme is to understand cancer signalling as networks of multiprotein machines which process information in a highly dynamic environment that is shaped by changing protein interactions and post-translational modifications (PTMs). Cancerous genetic mutations derange these protein networks in complex ways that are tractable by proteomics.

Publication DOI: https://doi.org/10.1038/nrc2900
Divisions: Life & Health Sciences > Pharmacy
Life & Health Sciences
Additional Information: Copyright © 2010, Springer Nature
Uncontrolled Keywords: animals,humans,neoplasms,protein binding,post-translational protein processing,protein-tyrosine kinases,proteomics,signal transduction,Cancer Research,Oncology
Full Text Link: https://researc ... ndle/10197/5073
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
Published Date: 2010-09
Authors: Kolch, Walter
Pitt, Andrew ( 0000-0003-3619-6503)

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