Spatial patterns of TDP-43 neuronal cytoplasmic inclusions (NCI) in fifteen cases of frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP)

Abstract

Neuronal cytoplasmic inclusions (NCI) immunoreactive for transactive response DNA-binding protein (TDP-43) are the pathological hallmark of frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP). We studied the spatial patterns of the TDP-43 immunoreactive NCI in the frontal and temporal cortex of 15 cases of FTLD-TDP. The NCI were distributed parallel to the tissue boundary predominantly in regular clusters 50-400 µm in diameter. In five cortical areas, the size of the clusters approximated to the cells of the cortico-cortical pathways. In most regions, cluster size was smaller than 400 µm. There were no significant differences in spatial patterns between familial and sporadic cases. Cluster size of the NCI was not correlated with disease duration, brain weight, Braak stage, or disease subtype. The spatial pattern of the NCI was similar to that of neuronal inclusions in other neurodegenerative diseases and may reflect a common pattern of degeneration involving the cortico-cortical projections.

Publication DOI: https://doi.org/10.1007/s10072-011-0639-8
Divisions: College of Health & Life Sciences > School of Optometry > Optometry
College of Health & Life Sciences > School of Optometry > Optometry & Vision Science Research Group (OVSRG)
College of Health & Life Sciences
College of Health & Life Sciences > School of Optometry > Vision, Hearing and Language
College of Health & Life Sciences > Clinical and Systems Neuroscience
Additional Information: The original publication is available at www.springerlink.com
Uncontrolled Keywords: frontotemporal lobar degeneration with TDP-43 proteinopathy,FTLD-TDP,TAR DNA-binding protein of 43 kDa,TDP-43,neuronal cytoplasmic inclusions,NCI,spatial pattern,Clinical Neurology,Psychiatry and Mental health,Dermatology
Publication ISSN: 1590-3478
Last Modified: 03 Jan 2024 17:07
Date Deposited: 19 Jul 2011 13:32
Full Text Link: http://www.spri ... 2464033h066766/
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2011-08
Authors: Armstrong, Richard A. (ORCID Profile 0000-0002-5046-3199)
Cairns, Nigel J.

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