Neuromuscular Transmission in Murine Muscular Dystrophy (129 ReJ Strain)

Abstract

Neuromuscular transmission in diaphragm and extensor digitorum longus (EDL) muscles from normal and dystrophic (129/Rej dy/dy) mice was compared using electrophysiological and pharmacological techniques. Indirectly evoked twitch responses of dystrophic EDL muscles were more resistant to curare than those of normal muscles whereas there was no difference in curare sensitivity between diaphragm muscles from normal and dystrophic mice. Spontaneous and evoked transmitter release was investigated using conventional intracellular recording techniques. Endplate potential (e.p.p.) amplitude and quantum content (m) were greater than normal in the dystrophic EDL. In the dystrophic diaphragm e.p.p. amplitude was larger, but m did not differ from normal. In the cut-fibre EDL transmitter release followed a binomial distribution. The probability of quantal release (p) and the number of quanta available for release (n) were calculated using the binomial model. Probability of release was greater in the dystrophic EDL but n was similar in normal and dystrophic muscles...

Publication DOI: https://doi.org/10.48780/publications.aston.ac.uk.00012486
Divisions: College of Health & Life Sciences
Additional Information: Copyright © Gareth P. Morgan, 1985. Gareth P. Morgan asserts their moral right to be identified as the author of this thesis. This copy of the thesis has been supplied on condition that anyone who consults it is understood to recognise that its copyright rests with its author and that no quotation from the thesis and no information derived from it may be published without appropriate permission or acknowledgement. If you have discovered material in Aston Publications Explorer which is unlawful e.g. breaches copyright, (either yours or that of a third party) or any other law, including but not limited to those relating to patent, trademark, confidentiality, data protection, obscenity, defamation, libel, then please read our Takedown Policy and contact the service immediately.
Institution: Aston University
Uncontrolled Keywords: Neuromuscular transmission,murine muscular dystrophy,(129 ReJ strain)
Last Modified: 25 Mar 2025 12:01
Date Deposited: 24 Jan 2011 14:19
Completed Date: 1985-03
Authors: Morgan, Gareth P.

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