Laminar distribution of the pathological changes in sporadic and variant Creutzfeldt-Jakob disease

Armstrong, Richard A. (2011). Laminar distribution of the pathological changes in sporadic and variant Creutzfeldt-Jakob disease. Pathology Research International, 2011 , pp. 1-7.

Abstract

The laminar distributions of the pathological changes in the cerebral cortex were compared in the prion diseases sporadic Creutzfeldt-Jakob disease (sCJD) and variant CJD (vCJD). First, in some cortical regions the vacuolation (‘spongiform change’) was more generally distributed across the cortex in sCJD. Second, there was greater neuronal loss in the upper cortex in vCJD and in the lower cortex in sCJD. Third, the ‘diffuse’ and ‘florid’ prion protein (PrPsc) deposits were more frequently distributed in the upper cortex in vCJD and the ‘synaptic’ deposits in the lower cortex in sCJD. Fourth, there was a significant gliosis mainly affecting the lower cortex of both disorders. The data suggest that the pattern of cortical degeneration is different in sCJD and vCJD which may reflect differences in aetiology and the subsequent spread of prion pathology in the brain.

Publication DOI: https://doi.org/10.4061/2011/236346
Divisions: Life & Health Sciences > Optometry
Life & Health Sciences > Ophthalmic Research Group
Life & Health Sciences > Health Sciences
Additional Information: Copyright © 2011 R. A. Armstrong. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Uncontrolled Keywords: laminar distributions,pathological changes,cerebral cortex,prion diseases sporadic,Creutzfeldt-Jakob disease,sCJD,variant CJD,vCJD,vacuolation,neuronal loss,prion protein,PrPsc,deposits,gliosis,cortical degeneration,aetiology,prion pathology,brain
Published Date: 2011

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